Pericardial fat from a single horizontal long axis cardiac magnetic resonance cine image: a validation study against three-dimensional cardiac computed tomography

Abstract Background Excess fat accumulation around the heart (i.e., pericardial fat) is positively associated with cardiovascular disease. Pericardial composed of two distinct depots: (1) epicardial fat, which a metabolically active adipose tissue located between and pericardium, (2) paracardial deposit in mediastinum outside parietal pericardium. Both depots are visible on horizontal long axis cardiac magnetic resonance (CMR) cine four chamber view), offering an attractive opportunity to quantify from standard CMR images. Purpose To validate area measured single against whole-heart volumetric non-contrast computed tomography (CT) measurements. Methods accomplish our goal, we leveraged 25 cases Women's Ischemia Syndrome Evaluation – Coronary Vascular Dysfunction Continuation cohort who underwent both MRI CT within median 35 days apart. For MRI, was high resolution steady state free precession image imaging plane using commercially available software (CVI42 V5.13.5, Circle Cardiovascular Imaging, Figure 1A). CT, volume fully automated deep learning algorithm (QFAT 2.0, Results Fat closely related by three-dimensional strong correlations for (R2=0.72, p<0.01, 1B), (R2=0.80, 1C), (R2=0.91, 1D). Conclusions Measuring area, its constituent parts, feasible strongly reference CT. Funding Acknowledgement Type funding sources: Public Institution(s). Main source(s): National Institutes Health